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Shown to Be Safe in Cats as Young as 8 weeks
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In pre-approval clinical studies, no adverse reactions were associated with the concurrent use of Revolution Plus and commonly prescribed veterinary products

Revolution Plus may be administered to cats with adult heartworm infection

In pre-approval clinical studies, no adverse reactions were associated with the concurrent use of Revolution Plus and commonly prescribed veterinary products

Revolution Plus may be administered to cats with adult heartworm infection

Adverse Reactions

In a field safety and effectiveness study, Revolution Plus was administered to cats with fleas. The study included a total of 430 cats (282 treated with Revolution Plus and 148 treated with imidacloprid + moxidectin once monthly for three treatments). Over the 90-day study period, all observations of potential adverse reactions were recorded. Reactions reported in the Revolution Plus group included those presented in the following table.

In a field safety and effectiveness study, Revolution Plus was administered to cats with fleas. The study included a total of 430 cats (282 treated with Revolution Plus and 148 treated with imidacloprid + moxidectin once monthly for three treatments). Over the 90-day study period, all observations of potential adverse reactions were recorded. Reactions reported in the Revolution Plus group included those presented in the following table.
REVOLUTION® PLUS n = 282 Active Control n = 148
Lethargy 12 (4.3%) 1 (0.7%)
Anorexia 9 (3.2%) 3 (2.0%)

Reasons You Love Revolution Plus

Reason #915

Because Trusted Parasite Protection Is Only a Few Clicks Away

Reasons You Love Revolution Plus

Reason #915

Because Trusted Parasite Protection Is Only a Few Clicks Away
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References:

  1. Data on file. Zoetis Inc.
  2. Revolution Plus (selamectin and sarolaner topical solution). Package insert. Zoetis Inc; 2023.
  3. Indoor Cats Parasiticides Tracker: “Stock Up” survey; fielded on 5/21-6/5/2018. Data on file. Zoetis Inc.
  4. Dryden MW, Canfield MS, Bocon C, et al. In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA. Parasit Vectors. 2018;11(1):422. doi:10.1186/s13071-018-2995-1
  5. Dryden MW, Herrin BH, Canfield MS, et al. Evaluation of a topical sarolaner-selamectin combination to control flea populations on naturally infested cats in private residences in West Central Florida. Vet Parasitol. 2020;283:109172. doi:10.1016/j.vetpar.2020.109172
  6. Study Report No. A186C-US-14-108. Data on file. Zoetis, Inc. 2014.
  7. Dipylidium caninum. Companion Animal Parasite Council. Updated November 22, 2022. Accessed May 3, 2023. https://capcvet.org/guidelines/dipylidium-caninum/
  8. Study Report No. A186C-US-14-100. Data on file. Zoetis, Inc. 2014.
  9. Study Report No. A186C-US-14-106. Data on file. Zoetis, Inc. 2014.
  10. Study Report No. A186C-US-14-098. Data on file. Zoetis, Inc. 2014.
  11. Otodectic mite. Companion Animal Parasite Council. Updated March 13, 2019. Accessed May 3, 2023. https://capcvet.org/guidelines/otodectic-mite/
  12. Study Report No. A186C-US-14-166. Data on file. Zoetis, Inc. 2017.
  13. Heartworm. Companion Animal Parasite Council. Updated July 28, 2020. Accessed September 23, 2022. https://capcvet.org/guidelines/heartworm/
  14. NexGard COMBO Package insert. Boehringer Ingelheim; 2023.
  15. Regions where ticks live. Centers for Disease Control and Prevention. Updated December 5, 2022. Accessed February 10, 2023. https://www.cdc.gov/ticks/geographic_distribution.html
  16. Ticks. Companion Animal Parasite Council. Updated April 12, 2017. Accessed February 10, 2023. https://www.capcvet.org/guidelines/ticks/
  17. Tick-borne diseases reported in most states, expert says. Companion Animal Parasite Council. Accessed February 10, 2023. https://capcvet.org/articles/tick-borne-diseases-reported-in-most-states-expert-says/

RVP-00610

IMPORTANT SAFETY INFORMATION

See full Prescribing Information. The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Sarolaner, one of the ingredients in Revolution Plus, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia, and seizures. Reactions have occurred in cats with or without a history of neurologic disorders. In humans, Revolution Plus may be irritating to skin and eyes. See full Prescribing Information.

Revolution Plus is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. Revolution Plus kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Ixodes scapularis (black-legged tick), Amblyomma maculatum (Gulf Coast tick) and Dermacentor variabilis (American dog tick), the treatment and control of ear mite (Otodectes cynotis) infestations, and the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.

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IMPORTANT SAFETY INFORMATION

See full Prescribing Information. The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Sarolaner, one of the ingredients in Revolution Plus, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia, and seizures. Reactions have occurred in cats with or without a history of neurologic disorders. In humans, Revolution Plus may be irritating to skin and eyes. See full Prescribing Information.

Revolution Plus is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. Revolution Plus kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Ixodes scapularis (black-legged tick), Amblyomma maculatum (Gulf Coast tick) and Dermacentor variabilis (American dog tick), the treatment and control of ear mite (Otodectes cynotis) infestations, and the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections for one month in cats and kittens 8 weeks and older, and weighing 2.8 pounds or greater.